What effect do alcohol and drugs, medication, stress, etc have on a person driving a vehicle?

• It will impair the judgment and ability to responsibly and safely operate a vehicle.
  Explanation:

  "Alcohol and drugs, some medications, stress, fatigue (mental, emotional, and physical), and lack of sleep will impair your judgment and ability to responsibly and safely operate a vehicle."
• It does not have any effect whatsoever.
• It can make you feel bad about driving alone.
• All of the above.